DN-1289 is an orally active and selective inhibitor of dual leucine zipper kinase (DLK, IC50=17 nM) and leucine zipper-bearing kinase (LZK, IC50=40 nM). DN-1289 results significant attenuation of optic nerve crush (ONC)-induced p-c-Jun in mice model. DN-1289 has excellent in vivo plasma half-life and blood-brain barrier permeability[1].
Molecular Weight:
441.38
Purity:
99.63
CAS Number:
[3026597-15-6]
Formula:
C18H19F4N7O2
Target:
JNK
Application Notes:
MCE Product type: Reference compound
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