EPZ004777 is an effective and selective DOT1L inhibitor, with IC50 being 0.4 nM. EPZ004777 reduces the levels of H3K79me2 and H3K79me1, significantly down-regulating the expression of HOXA9 and MEIS1. EPZ004777 selectively inhibits the proliferation of MLL rearrangement cells and promotes the differentiation and subsequent apoptosis (apoptosis) of leukemia cells. EPZ004777 can be used for the study of leukemia[1][2][3].
Molecular Weight:
539.67
Purity:
99.74
CAS Number:
[1338466-77-5]
Formula:
C28H41N7O4
Target:
Apoptosis,Histone Methyltransferase
Application Notes:
MCE Product type: Reference compound
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