JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2 (AIM 2) and non-canonical (NC) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1beta and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1[1].
Molecular Weight:
302.30
Purity:
98.03
CAS Number:
[937820-89-8]
Formula:
C17H15FO4
Target:
AIM2,NOD-like Receptor (NLR)
Application Notes:
MCE Product type: Reference compound
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