W1131 is a potent STAT3 inhibitor, triggering ferroptosis. W1131 suppresses cancer progression in gastric cancer cell subcutaneous xenograft model, organoids model, and PDX model. W1131 effectively alleviates chemical resistance of cancer cells to 5-FU (HY-90006). W1131 regulates cell cycle, DNA damage response, and oxidative phosphorylation, including IL6-JAK-STAT3 pathway and ferroptosis pathway[1].
Molecular Weight:
429.43
Purity:
99.45
CAS Number:
[2740522-79-4]
Formula:
C23H19N5O4
Target:
Ferroptosis,Oxidative Phosphorylation,STAT
Application Notes:
MCE Product type: Reference compound
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