W1131 TFA is a potent STAT3 inhibitor that induces ferroptosis. W1131 inhibits cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer. W1131 effectively alleviates cancer cell chemoresistance to 5-FU (HY-90006). W1131 regulates the cell cycle, DNA damage response, and oxidative phosphorylation, including the IL6-JAK-STAT3 pathway and the ferroptosis pathway[1].
Molecular Weight:
543.45
Purity:
99.27
Formula:
C25H20F3N5O6
Target:
Ferroptosis,STAT
Application Notes:
MCE Product type: Reference compound
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