Org 274179-0 is a potent and allosteric antagonist of thyroid-stimulating hormone (TSH) receptor, with an IC50 of nanomolar concentration. Org 274179-0 completely inhibits TSH (and TSI)-mediated TSH receptor activation with little effect on the potency of TSH. Org 274179-0 can be used for the research of Graves disease (GD)[1].
Molecular Weight:
480.52
Purity:
99.19
CAS Number:
[1421683-12-6]
Formula:
C28H27F3N2O2
Target:
TSH Receptor
Application Notes:
MCE Product type: Reference compound1
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