Org 274178-0 is a selective thyroid-stimulating hormone receptor (TSHR) antagonist with a pIC50 value for TSHR is 5.03. Org 274178-0 inhibits the activation of cAMP signaling pathway and phospholipase C (PLC) signaling pathway mediated by thyroid-stimulating hormone (TSH) and TSH receptor-stimulating immunoglobulins (TSIs). Org 274178-0 is promising for research of Graves disease and Graves ophthalmopathy[1].
Molecular Weight:
480.52
Purity:
99.40
Formula:
C28H27F3N2O2
Target:
TSH Receptor
Application Notes:
MCE Product type: Reference compound1
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