PRT062607 (P505-15, PRT-2607) is an orally active ATP-competitive Syk inhibitor with an IC50 value of 1 nM, and exhibits at least 80-fold selectivity over other kinases. PRT062607 blocks B cell antigen receptor-mediated activation, Fcepsilon receptor 1-mediated basophil degranulation and microglial phagocytosis, and induces caspase-dependent apoptosis and microglial death. PRT062607 inhibits tumor growth and peripheral nerve injury-induced mechanical allodynia, and prevents neuronal loss. PRT062607 can be used in research related to rheumatoid arthritis, chronic lymphocytic leukemia, non-Hodgkins lymphoma, neurodegenerative diseases and neuropathic pain[1][2][3][4].
Molecular Weight:
393.45
Purity:
99.38
CAS Number:
[1370261-96-3]
Formula:
C19H23N9O
Target:
Apoptosis,Caspase,Syk
Application Notes:
MCE Product type: Reference compound
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