Tagarafdeg (CFT1946) is an orally active, CRBN-based and mutant-selective bifunctional degradation activating compound (BiDAC) degrader of BRAFV600E with a DC50 of 14 nM in A375 cells. Tagarafdeg is capable of degrading BRAF V600E (Class I), G469A (Class II), G466V (Class III) mutations, and the p61-BRAFV600E splice variant. Tagarafdeg can be used in tumor research[1][2].
Molecular Weight:
958.00
Purity:
99.41
CAS Number:
[2882165-79-7]
Formula:
C45H49F2N11O9S
Target:
PROTACs,Raf
Application Notes:
Reference compound
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