MRT-2359 is a potent, orally active and selective GSPT1 depressant (IC50: >30 nM and apoptosis dependent on protein translation. MRT-2359 exhibits significant and preferred anti-proliferative activity in a variety of cancer cell lines, especially MYC-driven cell lines, such as non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) with high expression of N-Myc or L-Myc. MRT-2359 inhibits the growth of drug-resistant NSCLC and SCLC cells, making it suitable for cancer research[1][2][3][4][5].
Molecular Weight:
495.38
Purity:
99.98
CAS Number:
[2803881-11-8]
Formula:
C22H17F4N3O6
Target:
Apoptosis
Application Notes:
MCE Product type: Reference compound
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