I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM, Ki: 5.4 nM), structurally related to ML323 (HY-17543). I-138 induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells[1].
Molecular Weight:
492.50
Purity:
99.75
CAS Number:
[2098211-50-6]
Formula:
C26H23F3N6O
Target:
Deubiquitinase
Application Notes:
Reference compound
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