AMG 193 is an orally active MTA-cooperative PRMT5 inhibitor with antitumor activity. AMG 193, when complexed with MTA, preferentially inhibits the growth of MTAP-deficient tumor cells by inhibiting PRMT5 (IC50=0.107 µM), thereby protecting normal cells with wild-type MTAP[1][2].
Molecular Weight:
444.41
Purity:
99.71
CAS Number:
[2790567-82-5]
Formula:
C22H19F3N4O3
Target:
Histone Methyltransferase
Application Notes:
MCE Product type: Reference compound
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