LG100268 (LG268) is a potent, selective and orally active retinoid X receptor (RXR) agonist with EC50 values of 4 nM, 3 nM, and 4 nM for RXR-alpha, RXR-beta, and RXR-gamma, respectively[1]. LG100268 displays >1000-fold selectivity for RXR over RAR, the Ki values are 3.4 nM, 6.2 nM and 9.2 nM for RXR-alpha, RXR-beta, and RXR-gamma, respectively[2]. LG100268 activates RXR homodimers to induce transcriptional activation. LG100268 can be used for the study of lung carcinogenesisy[3].
Molecular Weight:
363.49
Purity:
99.39
CAS Number:
[153559-76-3]
Formula:
C24H29NO2
Target:
Autophagy,RAR/RXR
Application Notes:
MCE Product type: Reference compound
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