Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kalpha, PI3Kdelta, PI3Kbeta and PI3Kgamma, respectively. Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib has superior antitumor activity[1].
Molecular Weight:
480.52
Purity:
99.50
CAS Number:
[1032568-63-0]
Formula:
C23H28N8O4
Target:
Apoptosis,PI3K
Application Notes:
Reference compound
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