ErSO-TFPy (TEQ103) is an ERalpha+ tumor cell inhibitor with low nanomolar cytotoxic activity against ERalpha+ breast cancer cells. ErSO-TFPy activates the sodium channel TRPM4, causes an imbalance of intracellular calcium and sodium ions. ErSO-TFPy dysregulates calcium homeostasis in ERalpha+ tumor cells, triggers the anticipatory unfolded protein response, and induces rapid immune cell-independent necrotic cell death. ErSO-TFPy can be used for the research of estrogen receptor alpha positive breast cancer[1][2].
Molecular Weight:
434.31
Purity:
99.33
CAS Number:
[3035547-78-2]
Formula:
C19H13F7N2O2
Target:
Sodium Channel,TRP Channel
Application Notes:
MCE Product type: Reference compound
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