ErSO-TFPy activates the sodium channel TRPM4, causes an imbalance of intracellular calcium and sodium ions. ErSO-TFPy exhibits low nanomolar cytotoxicity in ERalpha+ breast cancer cell lines (IC50 = 5-25 nM) through induction of necrosis. ErSO-TFPy exhbits antitumor efficacy in mouse models[1].
Molecular Weight:
434.31
Purity:
99.33
CAS Number:
[3035547-78-2]
Formula:
C19H13F7N2O2
Target:
Sodium Channel,TRP Channel
Application Notes:
Reference compound
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