LD4172 is a selective RIPK1 PROTAC degrader with a Ki of 4.8 nM. LD4172 induces RIPK1 protein degradation via ternary complex formation with RIPK1 and VHL E3 ligase, driving ubiquitination and proteasomal breakdown. LD4172 abrogates TNF-induced classical NF-kappaB signaling in TRAF2-deficient cells, impairing IkappaBalpha phosphorylation and degradation, and reducing IL-8 production. LD4172 induces apoptosis and immunogenic cell death in tumor cells, enhances tumor-infiltrating lymphocyte responses, and sensitizes tumors to anti-PD1 therapy. LD4172 acts as a chemical probe for investigating RIPK1 scaffolding functions. LD4172 can be used for the research of melanoma, colon cancer[1][2].
Molecular Weight:
1149.37
Purity:
98.32
CAS Number:
[2782022-40-4]
Formula:
C61H75F3N10O7S
Target:
Apoptosis,PROTACs,RIP kinase
Application Notes:
MCE Product type: Reference compound1
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