LD4172 is a PROTAC degrader for RIP kinase (RIPK1) with DC50 in nanomolare levels. LD4172 induces apoptosis in cell B16F10 with combination of TNF-alpha. LD4172 exhibits antitumor efficacy in mouse models[1]. (Pink: ligand for target protein (HY-170613), Black: linker (HY-W012241), Blue: ligand for E3 ligase VHL (HY-112078))
Molecular Weight:
1149.37
Purity:
98.32
CAS Number:
[2782022-40-4]
Formula:
C61H75F3N10O7S
Target:
PROTACs,RIP kinase
Application Notes:
MCE Product type: Reference compound
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