PROTAC IRAK4 degrader-8 (Compound 2) is a PROTAC IRAK4 degrader (IC50: 15.5 nM). PROTAC IRAK4 degrader-8 degrades IRAK4 in THP-1 cells (DC50: 1.8 nM)PROTAC IRAK4 degrader-8 also inhibits L-6 production in human whole blood and LPS-induced human PBMC cells, with IC50s of 246 nM and 2.2 nM respectively[1].
Molecular Weight:
874.38
Purity:
99.70
CAS Number:
[2911615-06-8]
Formula:
C43H50ClF2N11O5
Target:
IRAK,PROTACs
Application Notes:
MCE Product type: Reference compound
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