Alcudacigib (ASP1570, DGKzeta-IN-1) TFA is an orally active diacylglycerol kinase zeta (DGKzeta) inhibitor, with an IC50 of 4.7 nM against human DGKzeta and an IC50 of 3.0 nM against mouse DGKzeta. Alcudacigib TFA selectively inhibits the kinase activity of DGKzeta and induces proteasome-dependent degradation of DGKzeta protein. Alcudacigib TFA enhances the anti-tumor functions of T cells and NK cells. Alcudacigib TFA can be used for the research of advanced/metastatic solid tumors[1][2].
Molecular Weight:
668.61
Purity:
99.72
Formula:
C29H26F6N6O4S
Target:
DGK,ERK,IFNAR,Interleukin Related
Application Notes:
MCE Product type: Reference compound
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