Antitumor agent-100 (compound A6) is an orally available apoptosis inducer and molecular gel targeting PDE3A-SLFN12 (IC50: 0.3 µM) with antitumor activity. Antitumor agent-100 binds to the PDE3A enzyme pocket to recruit and stabilize SLFN12, thereby preventing protein translation and leading to apoptosis[1].
Molecular Weight:
311.77
CAS Number:
[2841750-32-9]
Formula:
C17H14ClN3O
Target:
Apoptosis,Molecular Glues,Phosphodiesterase (PDE)
Application Notes:
MCE Product type: Reference compound
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