Zamaporvint (RXC004) is an orally active and selective inhibitor of Wnt. Zamaporvint targete membrane-bound o-acyltransferase Porcupine and inhibited Wnt ligand palmitoylation, secretion, and pathway activation. Zamaporvint displays a favorable pharmacokinetic profile and shows potent antiproliferative effects in Wnt ligand-dependent colorectal and pancreatic cell lines. Zamaporvint possesses multiple antitumor mechanisms and can be used in cancer research[1].
Molecular Weight:
439.39
Purity:
99.76
CAS Number:
[1900754-56-4]
Formula:
C21H16F3N7O
Target:
Acyltransferase,Porcupine,Wnt
Application Notes:
Reference compound
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