TAS2940 is a brain-penetrable, orally active, irreversible and selective pan-ERBB inhibitor. TAS2940 against wild-type HER2, HER2 V777L, and A775_G776insYVMA with IC50 values of 5.6 nM, 2.1 nM, and 1.0 nM, respectively. TAS2940 can be used for the study of tumors with HER2 and EGFR aberrations[1].
Molecular Weight:
482.58
CAS Number:
[2451398-65-3]
Formula:
C28H30N6O2
Target:
EGFR
Application Notes:
Reference compound
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