Lasmotinib (PHI-101) is a FLT3 and CHK2 inhibitor. Lasmotinib potently inhibits FLT3 single activating mutations (ITD or TKD mutants) and has inhibitory activity against FLT3 double (ITD/D835Y or ITD/F691L) and triple (ITD/D835Y/F691L) resistance mutations. Lasmotinib synergizes with Venetoclax (HY-15531) or Azacytidine to inhibit leukemia. Lasmotinib exhibits anticancer activity against ovarian and breast cancer[1][2][3][4].
Molecular Weight:
386.44
Purity:
98.97
CAS Number:
[2127107-15-5]
Formula:
C19H19FN4O2S
Target:
Checkpoint Kinase (Chk),FLT3
Application Notes:
Reference compound
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