Spiclomazine (Clospirazine) is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models[1].
Molecular Weight:
446.03
Purity:
99.95
CAS Number:
[24527-27-3]
Formula:
C22H24ClN3OS2
Target:
Ras
Application Notes:
MCE Product type: Reference compound
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