PRX-08066 (maleate), CAS [[866206-55-5]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-15472A
Supplier Catalog Number:
HY-15472A
Alternative Catalog Number:
MCE-HY-15472A-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
PRX-08066 maleate is a selective and orally active 5-hydroxytryptamine receptor 2B (5-HT2BR) antagonist with a Ki of 3.4 nM. PRX-08066 maleate inhibits the MAPK pathway, 5-HT release and fibrotic factor (TGFbeta1, CTGF and FGF2) expression. PRX-08066 maleate inhibits the proliferation of KRJ-I cells and induces apoptosis (caspase-3 activation). PRX-08066 maleate inhibits pulmonary vascular remodeling. PRX-08066 maleate can be used of pulmonary Arterial Hypertension (PAH) and neuroendocrine tumor (NET)[1][2].
