GSK-3 inhibitor 3 is a selective, orally active and brain-penetrant inhibitor of GSK-3, with IC50s of 0.35 nM and 0.25 nM for GSK-3alpha and GSK-3beta, respectively. GSK-3 inhibitor 3 lowers levels of tau protein phosphorylation at S396 in a triple-transgenic mouse Alzheimers disease model, with IC50 of 10 nM. GSK-3 inhibitor 3 can be used for neurological disease research[1].
Molecular Weight:
410.40
Purity:
99.10
CAS Number:
[2227279-84-5]
Formula:
C23H15FN6O
Target:
CDK,GSK-3,Tau Protein
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted
