GSK-3 inhibitor 4 is an orally active and brain-penetrant inhibitor of GSK-3, CDK2, and CDK5, with IC50 values of 0.56 nM (GSK-3beta), 0.45 nM (GSK-3alpha), 0.47 µM, and 0.68 µM, respectively. GSK-3 inhibitor 4 effectively reduces the phosphorylation level of Tau protein. GSK-3 inhibitor 4 can be used in Alzheimers disease (AD) studies[1].
Molecular Weight:
403.38
Purity:
99.02
CAS Number:
[2227279-83-4]
Formula:
C22H15F2N5O
Target:
CDK,GSK-3
Application Notes:
MCE Product type: Reference compound
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