DC-Y13-27 is a DC-Y13 derivative and YTHDF2 inhibitor (KD: 37.9 µM). DC-Y13-27 inhibits YTHDF2, restores FOXO3 and TIMP1 protein levels, and reduces MMP1/3/7/9 expression. DC-Y13-27 induces Pyroptosis and increases IL-1beta secretion. DC-Y13-27 reduces intervertebral disc degeneration and enhances the response to radiotherapy in colon cancer and melanoma. DC-Y13-27 has antitumor activity against breast cancer[1][2][3].
Molecular Weight:
270.31
Purity:
99.52
Formula:
C14H10N2O2S
Target:
FOXO,Interleukin Related,MMP,Pyroptosis,YTHDF
Application Notes:
MCE Product type: Reference compound
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