BMPR2-IN-1 is a selective BMPR2 inhibitor with a human BMPR2 IC50 of 506 nM and a Kd of 83.5 nM. BMPR2-IN-1 functions as an ATP mimetic, forming hydrogen bonds with the BMPR2 kinase domain backbone and hydrophobic interactions with specific residues, and demonstrates high selectivity for BMPR2 over other kinases.BMPR2-IN-1 can be used for the researches of cancer, pulmonary arterial hypertension and Alzheimers disease[1].
Molecular Weight:
321.34
Formula:
C16H15N7O
Target:
GSK-3,TGF-beta Receptor
Application Notes:
MCE Product type: Reference compound
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