NXE0041178 is an orally active and BBB-penetrant full GPR52 agonist, with a pEC50 of 7.5 for human GPR52 and an EC50 of 27.5 nM (pEC50 = 7.55) for rat GPR52. NXE0041178 shows no significant inhibition on hERG, hNaV1.5 and cytochrome P450 isoforms. NXE0041178 can reduce d-amphetamine-induced hyperactivity in rats. NXE0041178 can be used for research of Neurological disease[1][2].
Molecular Weight:
390.33
Purity:
99.97
CAS Number:
[2642079-89-6]
Formula:
C19H14F4N4O
Target:
GPR52
Application Notes:
MCE Product type: Reference compound
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