Antibacterial agent 144 (compound 8e) is an antibacterial agent,with better effect against multi-resistant Staphylococcus aureus than Chloromycin and Amoxicillin (HY-B0467A). Antibacterial agent 144 destroys the cytoplasmic membrane of bacteria,and inhibits the biofilms formation. Antibacterial agent 144 binds to HSA (Kd=13.2 µM),and exerts bactericidal efficacy. Antibacterial agent 144 also binds with DNA to for supramolecular complex to obstruct DNA replications[1].
Molecular Weight:
481.51
Formula:
C26H23N7O3
Target:
Bacterial,DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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