IR-251 is a mitochondrion-targeting NIR fluorescent probe. IR-251 targets mitochondria via OATPs and causes mitochondrial damage in tumor cells. IR-251 IR-251 induced ROS overproduction by inhibiting PPARgamma, and then inhibiting the beta-catenin signaling pathway and downstream protein molecules related to the cell cycle and metastasis. IR-251 inhibits tumor proliferation and metastasis[1].
Molecular Weight:
886.48
Formula:
C51H70BrClN4O2
Target:
Fluorescent Dye,Mitochondrial Metabolism,PPAR,Reactive Oxygen Species (ROS),beta-catenin
Application Notes:
MCE Product type: Dye Reagents
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