TRAP1-IN-1 (compound 35) is a potent and selective inhibitor of TRAP1,a mitochondrial isoform of Hsp90. TRAP1-IN-1 has >250-fold TRAP1 selectivity over Grp94,and disrupts TRAP1 tetramer stability,induces TRAP1 client protein degradation. TRAP1-IN-1 also inhibits mitochondrial complex I of oxidative phosphorylation OXPHOS,disrupts the mitochondrial membrane potential,and enhances glycolysis metabolism[1].
Molecular Weight:
866.74
Purity:
96.03
CAS Number:
[3031102-94-7]
Formula:
C45H39F7N2O4P2
Target:
HSP,Mitochondrial Metabolism
Application Notes:
MCE Product type: Reference compound
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