FC-11 is a tubulin inhibitor. FC-116 inhibits the proliferation of colorectal cancer (CRC) cells, with IC50 values of 4.52 nM for HCT116 cells and 18.69 nM for CT26 cells. FC-11 can induce ER stress to generate excess ROS, leading to mitochondrial damage, thereby promoting apoptosis in colorectal cancer (CRC) cells by targeting microtubules. FC-116 exerts potent anti-tumor effects in vivo. FC-11 can be used for the study of colorectal cancer[1].
Molecular Weight:
369.39
Purity:
98.04
CAS Number:
[2417298-29-2]
Formula:
C21H20FNO4
Target:
Apoptosis,Eukaryotic Initiation Factor (eIF),IRE1,Microtubule/Tubulin,PERK,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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