PROTAC BTK degraders-5(compound 3e) is a selective BTK PROTAC degrader with a DC50 value of 7.0 nM in JeKo-1 cells. PROTAC BTK degraders-5 has no off-target effect on degrading CRBN neosubstates. PROTAC BTK degraders-5 has anti-proliferation effect on various lymphoma tumor cells and can be used in chronic lymphoid malignancies research (Blue: E3 ligand (HY-W440230), Black: linker HY-168297,Pink:BKT inhibitor (HY-150898))1.
Molecular Weight:
958.52
Formula:
C52H57ClFN9O6
Target:
Btk,PROTACs
Application Notes:
MCE Product type: Reference compound
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