NC-R17 is a PROTAC-class, non-covalent GPX4 degrader based on RSL3, involved in ferroptosis. NC-R17 has antitumor activity and is used for non-covalent GPX4 PROTAC design[1]. NC-R17 consists of a target protein ligand (red part) Demethyl-RSL3 (HY-135832), an E3 ubiquitin ligase ligand (blue part) Lenalidomide (HY-A0003) and a PROTAC linker (black part) (HY-169376). E3 ubiquitin ligase and linker can form Lenalidomide-C13-piperazine-Boc (HY-169377)[1][2].
Molecular Weight:
914.14
CAS Number:
[3049087-34-2]
Formula:
C53H67N7O7
Target:
Ferroptosis,Glutathione Peroxidase,PROTACs
Application Notes:
MCE Product type: Reference compound
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