Semapimod, an inhibitor of proinflammatory cytokine production, can inhibit TNF-alpha, IL-1beta, and IL-6. Semapimod inhibits TLR4 signaling (IC50~0.3 µM). Semapimod inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod has potential in a variety of inflammatory and autoimmune disorders[1][2][3].
Molecular Weight:
744.90
CAS Number:
[352513-83-8]
Formula:
C34H52N18O2
Target:
Interleukin Related,p38 MAPK,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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