Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-alpha, IL-1beta, and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC50~0.3 µM). Semapimod tetrahydrochloride inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders[1][2][3].
Molecular Weight:
890.74
Purity:
98.43
CAS Number:
[164301-51-3]
Formula:
C34H56Cl4N18O2
Target:
Interleukin Related,p38 MAPK,TNF Receptor
Application Notes:
MCE Product type: Reference compound
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