Anticancer agent 154 (Compound 8h) increases the levels of reactive oxygen species and leads to mitochondrial damage. Anticancer agent 154 induces cell apoptosis and DNA damage. Anticancer agent 154 also induces ferroptosis by reducing the GSH level and GPX4 expression and increasing the lipid peroxidation level. Anticancer agent 154 inhibits cancer cell (HT29, H1975, A549, and MCF-7) proliferation with IC50s of 1.0-1.9 µM[1].
Molecular Weight:
389.45
Formula:
C22H23N5O2
Target:
Apoptosis,Ferroptosis,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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