ALK/EGFR-IN-1-d5, CAS [[2730429-93-1]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-155227S
Supplier Catalog Number:
HY-155227S
Alternative Catalog Number:
MCE-HY-155227S-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
ALK/EGFR-IN-1-d5 (Compound (-)-9a) is a deuterated dual-target inhibitor of EGFR and ALK, with an IC50 of 1.08 nM for EGFR and an IC50 of 2.395 nM for ALK. ALK/EGFR-IN-1-d5 inhibits the phosphorylated proteins in the EGFR, ALK, and BRK signaling pathways, blocking the cell cycle, leading to a reduction in mitochondrial membrane potential and cell apoptosis (Apoptosis). ALK/EGFR-IN-1-d5 also significantly inhibits tumor growth in animal models and demonstrates good safety. ALK/EGFR-IN-1-d5 holds promise for research in the field of cancer treatment[1]
