KGP591 is a tubulin polymerization inhibitor (IC50 0.57 µM). KGP591 induces significant G2/M stagnation, inhibits cell migration, disrupts microtubule structure and cell morphology in MDA-MB-231 cells. KGP591 shows antitumor activity in orthotopic model of kidney cancer (RENCA)[1].
Molecular Weight:
403.43
CAS Number:
[3018962-69-8]
Formula:
C24H21NO5
Target:
Microtubule/Tubulin
Application Notes:
MCE Product type: Reference compound
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