SARS-CoV-2-IN-60 (compound 5a) is an S-adenosylmethionine (SAM)-competitive and irreversible SARS-CoV-2 nsp16-nsp10 methyltransferase activity inhibitor with an IC50 of 9 µM and a Ki of 26 µM. SARS-CoV-2-IN-60 can specifically occupy a newly identified pocket adjacent to the SAM-binding site on nsp16. SARS-CoV-2-IN-60 has the potential for pan-coronavirus therapeutics[1].
Molecular Weight:
335.11
Purity:
99.22
Formula:
C13H7Cl2F3N2O
Target:
SARS-CoV
Application Notes:
MCE Product type: Reference compound1
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