YN14 is a KRASG12C proteolysis targeting chimera (PROTAC). YN14 is highly potent and selective KRASG12C degrader and induces a stable KRASG12C: YN14: VHL ternary complex with low binding free energy (deltaG). YN14 has antiproliferative effects and significantly inhibits KRASG12C-mutant cancer cell growth. YN14 leads to tumor regression with tumor growth inhibition (TGI%) rates more than 100 % in the MIA PaCa-2 xenograft model.
Molecular Weight:
1156.39
Purity:
99.0800
Formula:
C62H75F2N11O7S
Target:
PROTACs,Ras
Application Notes:
MCE Product type: Reference compound
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