Enpp-1-IN-19 (compound 29f) is an orally active ENPP1 inhibitor that inhibits cGAMP hydrolysis by ENPP1 (IC50=68 nM). Enpp-1-IN-19 increases anti-PD-L1 responses and inhibits tumor growth in CT26 syngeneic models. Enpp-1-IN-19 also enhances STING-mediated type I interferon responses, induces immune memory, and prevents tumor recurrence[1].
Molecular Weight:
344.39
Purity:
99.28
CAS Number:
[2738583-25-8]
Formula:
C16H16N4O3S
Target:
Phosphodiesterase (PDE),STING
Application Notes:
MCE Product type: Reference compound
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