NLRP3-IN-25 (compound 32) is an orally available NLRP3 inhibitor with anti-inflammatory activity. NLRP3-IN-25 attenuates renal injury in doxorubicin-induced glomerulonephritis in mice. NLRP3-IN-25 inhibits IL-1beta secretion in THP-1 cells with an IC50 of 21 nM[1].
Molecular Weight:
448.42
Purity:
99.78
CAS Number:
[2660230-90-8]
Formula:
C17H19F3N4O5S
Target:
Interleukin Related,NOD-like Receptor (NLR)
Application Notes:
MCE Product type: Reference compound
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