Cbl-b-IN-15 (compound 25) is an inhibitor of the RING finger E3 ligase Cbl (IC50: 15 nM). Cbl-b refers to Casitas B-lineage lymphoma proto-oncogene-b, which inhibits T-cell, natural killer (NK) cell, and B-cell activation. Cbl-b-IN-15 activates T cell function with EC50=0.41 µM[1].
Molecular Weight:
469.53
Formula:
C27H27N5O3
Target:
E1/E2/E3 Enzyme
Application Notes:
MCE Product type: Reference compound1
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