INF200 (compound 5) is a sulfonylurea-based inhibitor of NLRP3 and NLRP3-mediated pyroptosis. INF200 has beneficial cardiometabolic effects in rat model of high-fat diet (HFD)-induced metaflammation,and shows anti-inflammatory activity to (10 µM) decreases IL-1beta release in human macrophages. INF200 improves glucose and lipid profiles,and attenuates systemic inflammation and biomarkers of cardiac dysfunction (particularly BNP). INF200 also improves myocardial damage-dependent ischemia/reperfusion injury (IRI) in hemodynamic evaluation[1].
Molecular Weight:
296.71
Formula:
C13H13ClN2O4
Target:
NOD-like Receptor (NLR),Pyroptosis
Application Notes:
MCE Product type: Reference compound1
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