Antileishmanial agent-19 (Compound F27) is an antileishmanial agent, with a IC50 of 3.39 µM for L. donovani promastigotes. Antileishmanial agent-19 inhibits Leishmania prolyl-tRNA synthetase. Antileishmanial agent-19 inhibits host PI3K/Akt/CREB axis-mediated IL-10 secretion. Antileishmanial agent-19 induces autophagy-mediated apoptosis in L. donovani promastigotes. Antileishmanial agent-19 reduces parasite burden in L.d-infected animals[1].
Molecular Weight:
386.40
Purity:
99.45
Formula:
C22H18N4O3
Target:
Parasite
Application Notes:
MCE Product type: Reference compound1
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