Tubulin/HDAC-IN-2 (Compound II-19k) is a dual inhibitor of Tubulin and HDAC, with an IC50 of 0.403 µM, 0.591µM, 3.552µM, 0.459µM for HDAC1/2/3/6. Tubulin/HDAC-IN-2 blocks cell cycle arrest at G2 phase, induces cell apoptosis. Tubulin/HDAC-IN-2 inhibits the growth of hematoma and solid tumor cells, reduces tumor metastasis, and also inhibits tumor growth in a liver tumor allograft mouse model[1].
Molecular Weight:
382.38
Formula:
C21H19FN2O4
Target:
Apoptosis,HDAC,Microtubule/Tubulin
Application Notes:
MCE Product type: Reference compound
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