SA-VA is an intracellular self-assembled PROTAC based on azide and alkyne. SA-VA is able to selectively degrade VEGFR-2 and EphB4 proteins in U87 cells. SA-VA can be converted to PROTAC in situ by click reaction with the help of endogenous copper in tumor tissues. SA-VA promotes apoptosis and blocks cells in S phase[1].
Molecular Weight:
1044.54
Formula:
C50H53ClF3N11O7S
Target:
Apoptosis,Ephrin Receptor,PROTACs,VEGFR
Application Notes:
MCE Product type: Reference compound
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