HMGB1-IN-2 (compound 15) is an inhibitor of highly conserved nuclear protein (HMGB1), showing NO inhibitory effect with IC50 value of 20.2 µM in RAW264.7 cells. HMGB1-IN-2 (30 µM) decreases the level of IL-1 beta, TNF-alpha, caspase-1 p20, inhibits the phosphorylation of NF-kappaB p65, exhibits anti-apoptotic activity. HMGB1-IN-2 (15 mg/kg, ip) relives kidney injury in septic acute kidney injury mouse. HMGB1-IN-2 inhibits Huh7 cells and A549 cells with IC50s of 77.0 µM, and 82.0 µM, respectively[1].
Molecular Weight:
926.14
Formula:
C53H71N3O11
Target:
Apoptosis,Caspase,Interleukin Related,NF-kappaB
Application Notes:
MCE Product type: Reference compound1
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